Endocrine Abstracts

The hair follicle is the most prominent cutaneous mini-organ and one of the defining features of mammalian species. Hair follicle development is driven and controlled by a series of precisely choreographed, reciprocal epithelial?mesenchymal interactions involving secreted growth factors, differentially expressed growth factor receptors and transcription factors, adhesion molecules and changes in the extracellular matrix milieu. Key amongst these signalling pathways during earl...

Liver X receptors α and β (NR1H3 and NR1H2) play major a role within cells and tissues involved in lipid metabolism and cholesterol homeostasis including macrophages, the liver and the small intestine. Within the skin however, the roles of LXR are less well documented, although in vitro studies using primary human keratinocytes have implemented LXR in the formation of the stratum corneum via the increase of transcription of the proteins involved in the AP-1 co...